Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.62 |
| ▸ | RAB9A | P51151 | 6/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.57 |
| ▸ | CASP1 | P29466 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL14812337 | 0.90 | CNR2 (0.54) | NPC1RAB9AMEN1KMT2AHDAC8 | |
| SCHEMBL14812072 | 0.89 | EPHX2 (0.65) | NPC1RAB9AMEN1KMT2AHDAC8 | |
| SCHEMBL4917828 | 0.87 | RAB9A (0.68) | NPC1RAB9AEGFRALDH1A1L3MBTL1 | |
| SCHEMBL14811905 | 0.87 | EPHX2 (0.54) | NPC1RAB9AMEN1KMT2AHDAC8 | |
| SCHEMBL7981993 | 0.85 | HDAC3 (0.64) | NPC1RAB9AEGFREPHX2HDAC3 | |
| SCHEMBL7970712 | 0.85 | NPC1 (0.62) | NPC1RAB9AEGFREPHX2HDAC3 | |
| SCHEMBL906398 | 0.85 | RAB9A (0.62) | NPC1RAB9AKMT2AEGFRALDH1A1 | |
| SCHEMBL9800175 | 0.85 | NPC1 (0.62) | NPC1RAB9AEGFRALDH1A1EPHX2 | |
| SCHEMBL13607002 | 0.85 | NPC1 (0.62) | NPC1RAB9AEGFRALDH1A1EPHX2 | |
| SCHEMBL7381527 | 0.83 | NPC1 (0.61) | NPC1RAB9AEGFREPHX2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101370790-B | As pyridine and the pyrimidine derivatives of NSC 630176 | JANSSEN PHARMACEUTICA N.V. (BE) | 2015-10-21 | — | — | CN | disclosed |
| EP-2810944-A1 | HETEROCYCLIC COMPOUND HAVING ANTI-HIV ACTIVITY | Toyama Chemical Co., Ltd. (JP) | 2014-12-10 | — | — | EP | disclosed |
| CN-101370804-B | Novel aminophenyl derivatives as histone deacetylase inhibitors | JANSSEN PHARMACEUTICA NV | 2013-05-29 | — | — | CN | disclosed |
| CN-101370789-B | Pyridine and pyrimidine derivatives as histone deacetylase inhibitors | JANSSEN PHARMACEUTICA NV | 2012-05-30 | — | — | CN | disclosed |
| CN-101370791-B | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA NV | 2012-05-02 | — | — | CN | disclosed |
| CN-1993353-B | Substituted indolyl alkylamino derivatives as novel inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA NV | 2010-12-01 | — | — | CN | disclosed |
| CN-101370789-A | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA NV (BE) | 2009-02-18 | — | — | CN | disclosed |
| CN-101370790-A | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA NV (BE) | 2009-02-18 | — | — | CN | disclosed |
| CN-101370804-A | Novel aminophenyl derivatives as histone deacetylase inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2009-02-18 | — | — | CN | disclosed |
| CN-101370791-A | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA NV (BE) | 2009-02-18 | — | — | CN | disclosed |
| CN-1993353-A | Substituted indolyl alkylamino derivatives as novel inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA NV (BE) | 2007-07-04 | — | — | CN | disclosed |
| WO-2001019373-A2 | METHODS AND COMPOSITIONS FOR MODULATING RESPONSIVENESS TO CORTICOSTEROIDS | BASF AKTIENGESELLSCHAFT (DE) | 2001-03-22 | — | — | WO | disclosed |
| CN-1269722-A | Method and composition for modulating responsiveness to corticosteroids | BASF AG (DE) | 2000-10-11 | — | — | CN | disclosed |
| EP-0998300-A1 | METHODS AND COMPOSITIONS FOR MODULATING RESPONSIVENESS TO CORTICOSTEROIDS | BASF AKTIENGESELLSCHAFT (DE) | 2000-05-10 | — | — | EP | disclosed |
| US-5919790-A | ANTIINFLAMMATORY AGENT; THERAPY FOR STROKE, SEPTIC SHOCK;ALZHEIMER*S DISEASE | WARNER-LAMBERT COMPANY (US) | 1999-07-06 | — | — | US | disclosed |
| WO-1998041232-A2 | COMPOSITIONS FOR MODULATING RESPONSIVENESS TO CORTICOSTEROIDS | BASF AKTIENGESELLSCHAFT (DE) | 1998-09-24 | — | — | WO | disclosed |