Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | CFTR | P13569 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.36 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5057519 | 0.80 | NPC1 (0.50) | NPC1MAPTRAB9AMCL1HSD17B10 | |
| SCHEMBL10633577 | 0.80 | NPC1 (0.50) | NPC1MAPTRAB9AMCL1HSD17B10 | |
| SCHEMBL18628737 | 0.80 | NPC1 (0.50) | NPC1MAPTRAB9AMCL1HSD17B10 | |
| SCHEMBL9078237 | 0.80 | NPC1 (0.56) | NPC1MAPTRAB9AMCL1HSD17B10 | |
| SCHEMBL4947911 | 0.80 | NPC1 (0.60) | NPC1MAPTRAB9AMCL1HSD17B10 | |
| SCHEMBL6507233 | 0.78 | PARP1 (0.42) | NPC1MAPTRAB9AHSD17B10ALDH1A1 | |
| SCHEMBL8548519 | 0.76 | MAPT (0.47) | NPC1MAPTRAB9AMCL1HSD17B10 | |
| SCHEMBL4768227 | 0.76 | NPC1 (0.60) | NPC1MAPTRAB9AMCL1HSD17B10 | |
| SCHEMBL18853940 | 0.76 | NPC1 (0.60) | NPC1MAPTRAB9AMCL1HSD17B10 | |
| SCHEMBL2080582 | 0.76 | NPC1 (0.47) | NPC1MAPTRAB9AMCL1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0700913-B1 | 5,6-dihydro-4H-imidazo(4,5,1-ij)quinolines, processes for their preparation, their use as medicaments, and intermediate compounds | HOECHST MARION ROUSSEL INC (US) | 1998-06-03 | — | — | EP | claimed |
| EP-0700913-A1 | 5,6-dihydro-4H-imidazo(4,5,1-ij)quinolines, processes for their preparation, their use as medicaments, and intermediate compounds | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1996-03-13 | — | — | EP | claimed |
| JP-8092251-A | — | — | None | — | — | JP | disclosed |
| JP-7179466-A | — | — | None | — | — | JP | disclosed |
| US-9745299-B2 | Substituted tricyclic benzimidazoles as kinase inhibitors | SELVITA SA (PL) | 2017-08-29 | — | — | US | disclosed |
| US-9745299-B2 | Substituted tricyclic benzimidazoles as kinase inhibitors | SELVITA SA (PL) | 2017-08-29 | — | — | US | disclosed |
| US-9745299-B2 | Substituted tricyclic benzimidazoles as kinase inhibitors | SELVITA SA (PL) | 2017-08-29 | — | — | US | disclosed |
| EP-2917217-B1 | SUBSTITUTED TRICYCLIC BENZIMIDAZOLES AS KINASE INHIBITORS | SELVITA S A (PL) | 2017-03-08 | — | — | EP | disclosed |
| US-20150274726-A1 | SUBSTITUTED TRICYCLIC BENZIMIDAZOLES AS KINASE INHIBITORS | SELVITA SA (PL) | 2015-10-01 | — | — | US | disclosed |
| EP-0700913-B1 | 5,6-dihydro-4H-imidazo(4,5,1-ij)quinolines, processes for their preparation, their use as medicaments, and intermediate compounds | HOECHST MARION ROUSSEL INC (US) | 1998-06-03 | — | — | EP | disclosed |
| US-5589476-A | TREATMENT OF NAUSEA, VOMITING AND GASTROINTESTINAL DISORDERS | SYNTHELABO (FR) | 1996-12-31 | — | — | US | disclosed |
| US-5563272-A | ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1996-10-08 | — | — | US | disclosed |
| JP-H0892251-A | 5,6-DIHYDRO-4H-IMIDAZO(4,5,1-IJ)QUINOLINES, THEIR PRODUCTION, USE THEREOF AS MEDICAMENT AND INTERMEDIATE COMPOUND | HOECHST ROUSSEL PHARMACEUT INC | 1996-04-09 | — | — | JP | disclosed |
| US-5500423-A | ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1996-03-19 | — | — | US | disclosed |
| EP-0700913-A1 | 5,6-dihydro-4H-imidazo(4,5,1-ij)quinolines, processes for their preparation, their use as medicaments, and intermediate compounds | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1996-03-13 | — | — | EP | disclosed |
| JP-H07179466-A | IMIDAZOL-4-YLPIPERIDINE DERIVATIVE, ITS PREPARATION, AND APPLICATION THEREOF IN MEDICINE | SYNTHELABO SA | 1995-07-18 | — | — | JP | disclosed |
| EP-0646583-A1 | Derivatives of Imidezol-4-yl piperidine, their preparation and use in therapy | SYNTHELABO (FR) | 1995-04-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150274726-A1 | SUBSTITUTED TRICYCLIC BENZIMIDAZOLES AS KINASE INHIBITORS | CDK8, CDK18, CDK9 | NPC1 4696/4885MAPT 3120/4885RAB9A 1596/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.