Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.54 |
| ▸ | ACE | P12821 | 3/20 | 0.54 |
| ▸ | GRN | P28799 | 3/20 | 0.36 |
| ▸ | SORT1 | Q99523 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 4/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.34 |
| ▸ | NPR3 | P17342 | 2/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7531333 | 0.89 | ACE2 (0.55) | ACE2ACEGRNSORT1KMT2A | |
| SCHEMBL1655474 | 0.89 | ACE2 (0.64) | ACE2ACEGRNSORT1CYP11B1 | |
| SCHEMBL3704484 | 0.89 | ACE2 (0.64) | ACE2ACEGRNSORT1CYP11B1 | |
| SCHEMBL7384416 | 0.86 | ACE2 (0.52) | ACE2ACEGRNSORT1CYP11B1 | |
| SCHEMBL7424805 | 0.81 | ACE2 (0.54) | ACE2ACEGRNSORT1MAPT | |
| SCHEMBL7421732 | 0.81 | ACE2 (0.54) | ACE2ACEGRNSORT1CYP11B1 | |
| SCHEMBL5869894 | 0.80 | ACE2 (0.81) | ACE2ACEGRNSORT1MAPT | |
| SCHEMBL5869891 | 0.80 | ACE2 (0.81) | ACE2ACEGRNSORT1MAPT | |
| SCHEMBL5870288 | 0.80 | ACE2 (0.81) | ACE2ACEGRNSORT1MAPT | |
| SCHEMBL3680172 | 0.80 | ACE2 (0.52) | ACE2ACEGRNSORT1CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | claimed |