Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.55 |
| ▸ | ACE | P12821 | 3/20 | 0.55 |
| ▸ | GRN | P28799 | 3/20 | 0.37 |
| ▸ | SORT1 | Q99523 | 3/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.35 |
| ▸ | PPID | Q08752 | 1/20 | 0.32 |
| ▸ | FNTA | P49354 | 2/20 | 0.32 |
| ▸ | FNTB | P49356 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3704484 | 0.90 | ACE2 (0.64) | ACE2ACEGRNSORT1CYP11B1 | |
| SCHEMBL1655474 | 0.90 | ACE2 (0.64) | ACE2ACEGRNSORT1CYP11B1 | |
| SCHEMBL7384416 | 0.89 | ACE2 (0.52) | ACE2ACEGRNSORT1CYP11B1 | |
| SCHEMBL7424864 | 0.89 | ACE2 (0.54) | ACE2ACEGRNSORT1CYP11B1 | |
| SCHEMBL7424805 | 0.84 | ACE2 (0.54) | ACE2ACEGRNSORT1CYP11B1 | |
| SCHEMBL7421732 | 0.82 | ACE2 (0.54) | ACE2ACEGRNSORT1CYP11B1 | |
| SCHEMBL7427935 | 0.82 | ACE2 (0.66) | ACE2ACEGRNSORT1CYP11B1 | |
| SCHEMBL3680172 | 0.81 | ACE2 (0.52) | ACE2ACEGRNSORT1CYP11B1 | |
| SCHEMBL7382791 | 0.81 | ACE2 (0.49) | ACE2ACEGRNSORT1CYP11B1 | |
| SCHEMBL3709303 | 0.81 | ACE2 (0.52) | ACE2ACECYP11B1CYP11B2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | disclosed |