Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.73 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | BMP1 | P13497 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7334434 | 0.89 | KCNH2 (0.91) | KCNH2MAPTKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL8632057 | 0.85 | KCNH2 (0.70) | KCNH2MAPTKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL30357973 | 0.84 | KCNH2 (1.00) | KCNH2MAPTKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL7326893 | 0.84 | KCNH2 (0.79) | KCNH2MAPTKMT2ASMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL7333187 | 0.84 | KCNH2 (0.98) | KCNH2MAPTKMT2ASMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL678425 | 0.83 | KCNH2 (0.96) | KCNH2MAPTKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL7334691 | 0.81 | KCNH2 (0.76) | KCNH2MAPTKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL7324517 | 0.80 | KCNH2 (0.75) | KCNH2MAPTKMT2ASMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL7333194 | 0.79 | KCNH2 (0.74) | KCNH2MAPTKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL7332923 | 0.79 | KCNH2 (0.88) | KCNH2MAPTKMT2ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0639973-A1 | DIAMINES IN THE TREATMENT OF ARRHYTHMIA | SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES (FR) | 1995-03-01 | — | — | EP | claimed |
| WO-1993023024-A1 | DIAMINES IN THE TREATMENT OF ARRHYTHMIA | SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES (FR) | 1993-11-25 | — | — | WO | claimed |