Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.58 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.58 |
| ▸ | PDE4A | P27815 | 15/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 15/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 15/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 15/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7441966 | 0.85 | PDE3B (0.57) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10632835 | 0.82 | PDE3B (0.53) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7435632 | 0.80 | PDE3B (0.57) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7440629 | 0.79 | PDE3B (0.59) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7431462 | 0.78 | PDE3B (0.56) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10632511 | 0.76 | PDE3B (0.52) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7434193 | 0.75 | PDE3B (0.70) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL2240328 | 0.75 | L3MBTL1 (0.47) | BRD4 | |
| SCHEMBL7426497 | 0.74 | PDE3B (0.64) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7436174 | 0.74 | PDE3B (0.53) | PDE3BPDE3APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4405628-A | 4-Pyridylimidazolones and method of use | MERRELL DOW PHARMACEUTICALS INC. (US) | 1983-09-20 | — | — | US | disclosed |
| EP-0059948-A1 | Novel aroylimidazolones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1982-09-15 | — | — | EP | disclosed |