Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 18/20 | 0.72 |
| ▸ | PDE4A | P27815 | 16/20 | 0.60 |
| ▸ | PDE4B | Q07343 | 16/20 | 0.60 |
| ▸ | PDE4C | Q08493 | 16/20 | 0.60 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.59 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15270505 | 0.84 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL7421089 | 0.82 | PDE4D (0.66) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL30614194 | 0.82 | PDE4D (0.81) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL2908650 | 0.82 | PDE4D (0.81) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL6874729 | 0.82 | PDE4D (0.81) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL8891373 | 0.81 | PDE4D (0.65) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL8891383 | 0.81 | PDE4D (0.65) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL7353919 | 0.80 | PDE4D (0.73) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL7357641 | 0.79 | PDE4D (0.83) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL7353637 | 0.78 | PDE4D (0.81) | PDE4DPDE4APDE4BPDE4CCYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995004046-A1 | COMPOUNDS AS PDE IV AND TNF INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1995-02-09 | — | — | WO | claimed |
| WO-1995004046-A1 | COMPOUNDS AS PDE IV AND TNF INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1995-02-09 | — | — | WO | disclosed |