Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 10/20 | 0.65 |
| ▸ | PDE4A | P27815 | 8/20 | 0.58 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.58 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.58 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.54 |
| ▸ | SNCA | P37840 | 2/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8891383 | 1.00 | PDE4D (0.65) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL7425558 | 0.81 | PDE4D (0.72) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL8890532 | 0.81 | PDE4D (0.70) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL30614148 | 0.80 | PDE4D (0.68) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL15270505 | 0.79 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL8890987 | 0.78 | PDE4D (0.66) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL7421089 | 0.78 | PDE4D (0.66) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL30614194 | 0.77 | PDE4D (0.81) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL2908650 | 0.77 | PDE4D (0.81) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL6874729 | 0.77 | PDE4D (0.81) | PDE4DPDE4APDE4BPDE4CCYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997003967-A1 | SUBSTITUTED AROMATIC COMPOUNDS AND THEIR PHARMACEUTICAL USE | RHONE-POULENC RORER LIMITED (GB) | 1997-02-06 | — | — | WO | claimed |
| WO-1997003967-A1 | SUBSTITUTED AROMATIC COMPOUNDS AND THEIR PHARMACEUTICAL USE | RHONE-POULENC RORER LIMITED (GB) | 1997-02-06 | — | — | WO | disclosed |