Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NNMT | P40261 | 4/20 | 0.35 |
| ▸ | PLAU | P00749 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | MC4R | P32245 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | MC3R | P41968 | 1/20 | 0.31 |
| ▸ | WEE1 | P30291 | 1/20 | 0.31 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.31 |
| ▸ | SELE | P16581 | 1/20 | 0.31 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14791400 | 0.82 | SIRT6 (0.37) | SIRT6POLBNNMTTSHRLMNA | |
| SCHEMBL14791396 | 0.81 | SIRT6 (0.36) | SIRT6POLBNNMTLMNA | |
| SCHEMBL31574399 | 0.80 | SIRT6 (0.38) | SIRT6POLBNNMTPLAUTSHR | |
| SCHEMBL23235003 | 0.73 | POLB (0.40) | SIRT6POLBNNMTPLAUTSHR | |
| SCHEMBL16177025 | 0.72 | SIRT6 (0.38) | SIRT6POLBNNMTPLAUTSHR | |
| SCHEMBL1703067 | 0.72 | ICAM1 (0.47) | SIRT6POLBNNMTTSHRLMNA | |
| SCHEMBL29688314 | 0.71 | HPGD (0.36) | POLBPLAUTSHRHSD17B10SMN1; SMN2 | |
| SCHEMBL5898805 | 0.71 | HPGD (0.36) | POLBPLAUTSHRHSD17B10SMN1; SMN2 | |
| SCHEMBL31368718 | 0.71 | POLB (0.38) | SIRT6POLBNNMTTSHRLMNA | |
| SCHEMBL17185607 | 0.71 | SIRT6 (0.37) | SIRT6POLBNNMTTSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054884-A1 | BENZOFURAN-4-CARBOXAMIDES AND THEIR THERAPEUTIC USE | Darwin Discovery Limited (GB) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999040085-A1 | BENZOFURAN-4-CARBOXAMIDES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LIMITED (GB) | 1999-08-12 | — | — | WO | disclosed |