Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 13/20 | 1.00 |
| ▸ | MMP2 | P08253 | 8/20 | 1.00 |
| ▸ | MMP9 | P14780 | 3/20 | 1.00 |
| ▸ | MMP1 | P03956 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7664040 | 1.00 | ADAM17 (1.00) | ADAM17MMP2MMP9MMP1 | |
| Trifluoroacetic Acid SCHEMBL7665967 | 0.95 | ADAM17 (0.91) | ADAM17MMP2MMP9MMP1 | |
| SCHEMBL7664231 | 0.92 | ADAM17 (1.00) | ADAM17MMP2MMP9MMP1 | |
| SCHEMBL7425028 | 0.92 | ADAM17 (1.00) | ADAM17MMP2MMP9MMP1 | |
| SCHEMBL7433235 | 0.91 | ADAM17 (1.00) | ADAM17MMP2MMP9MMP1 | |
| SCHEMBL7670103 | 0.89 | ADAM17 (0.91) | ADAM17MMP2MMP9MMP1 | |
| SCHEMBL7672984 | 0.89 | ADAM17 (1.00) | ADAM17MMP2MMP9MMP1 | |
| SCHEMBL7430421 | 0.88 | ADAM17 (0.81) | ADAM17MMP2MMP9MMP1 | |
| SCHEMBL7433372 | 0.88 | ADAM17 (1.00) | ADAM17MMP2MMP9MMP1 | |
| Trifluoroacetic Acid SCHEMBL7661679 | 0.88 | ADAM17 (0.92) | ADAM17MMP2MMP9MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165546-A2 | NOVEL LACTAM INHIBITORS OF MATRIX METALLOPROTEINASES, TNF-ALPHA, AND AGGRECANASE | Du Pont Pharmaceuticals Company (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059285-A2 | NOVEL LACTAM INHIBITORS OF MATRIX METALLOPROTEINASES, TNF-α, AND AGGRECANASE | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-10-12 | — | — | WO | disclosed |