Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | EP300 | Q09472 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 4/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 3/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7426330 | 1.00 | KDM4E (0.37) | KDM4EEP300MITFPDE4APDE4B | |
| Bromide SCHEMBL7388094 | 0.82 | KDM4E (0.33) | KDM4EEP300PDE4APDE4BPDE4C | |
| Bromide SCHEMBL7388095 | 0.82 | KDM4E (0.33) | KDM4EEP300PDE4APDE4BPDE4C | |
| Bromide SCHEMBL7432805 | 0.82 | KDM4E (0.33) | KDM4EEP300PDE4APDE4BPDE4C | |
| SCHEMBL7392141 | 0.82 | ALDH1A1 (0.38) | KDM4EEP300MITFPDE4APDE4B | |
| SCHEMBL7392140 | 0.82 | ALDH1A1 (0.38) | KDM4EEP300MITFPDE4APDE4B | |
| SCHEMBL7382774 | 0.81 | CACNA1F (0.35) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7427999 | 0.81 | CACNA1F (0.35) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7382772 | 0.81 | CACNA1F (0.35) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7444417 | 0.81 | EHMT2 (0.35) | PDE4APDE4BPDE4CPDE4DLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001064647-A1 | ISOQUINOLINE DERIVATIVES AS PDE4 INHIBITORS | SANOFI-SYNTHELABO (FR) | 2001-09-07 | — | — | WO | disclosed |