SCHEMBL7426754

SCHEMBL7426754

N[C@H](C=O)Cc1ccc(OCc2ccccc2)cc1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LTA4H P09960 3/20 0.61
LAP3 P28838 1/20 0.57
MAOB P27338 2/20 0.54
BCHE P06276 1/20 0.54
PPARG P37231 2/20 0.54
PPARA Q07869 2/20 0.54
GAA P10253 1/20 0.53
MAPT P10636 1/20 0.53
MAOA P21397 1/20 0.53
RAB9A P51151 1/20 0.53
SMN1; SMN2 Q16637 1/20 0.53
L3MBTL1 Q9Y468 1/20 0.53
FFAR1 O14842 1/20 0.53
FFAR4 Q5NUL3 1/20 0.53
GSTP1 P09211 1/20 0.50
PARP10 Q53GL7 1/20 0.50
CA12 O43570 1/20 0.50
CA1 P00915 1/20 0.50
CA2 P00918 1/20 0.50
CA4 P22748 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14279482 1.00 LTA4H (0.61) LTA4HLAP3MAOBBCHEPPARG
SCHEMBL7434755 1.00 LTA4H (0.61) LTA4HLAP3MAOBBCHEPPARG
SCHEMBL5784530 0.86 MAOB (0.54) LTA4HMAOBBCHEGAAMAPT
SCHEMBL2639450 0.83 EPHX1 (0.56) LAP3MAOACYP1A2PTGS1SLC6A2
SCHEMBL6486058 0.83 EPHX1 (0.56) LAP3MAOACYP1A2PTGS1SLC6A2
SCHEMBL7327748 0.83 EPHX1 (0.56) LAP3MAOACYP1A2PTGS1SLC6A2
SCHEMBL309963 0.83 EPHX1 (0.56) LAP3MAOACYP1A2PTGS1SLC6A2
SCHEMBL623688 0.83 EPHX1 (0.56) LAP3MAOACYP1A2PTGS1SLC6A2
SCHEMBL14423619 0.82 LTA4H (0.62) LTA4HLAP3MAOBBCHEPPARG
SCHEMBL26082413 0.81 MAOB (0.56) LTA4HMAOBBCHEPPARGPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0127899-B1 CYCLIC PENTAPEPTIDES DISPLAYING SOMATOSTATIN ANTAGONISM AND METHOD OF TREATMENT OF MAMMALS THEREWITH The Administrators of The Tulane University Educational Fund (US) 1987-10-21 EP claimed
EP-0188214-A2 Novel growth hormone-releasing peptides and method of treating mammals therewith The Administrators of The Tulane University Educational Fund (US) 1986-07-23 EP claimed
EP-0145768-A1 CYCLIC PENTAPEPTIDES DISPLAYING SOMATOSTATIN ANTAGONISM AND METHOD OF TREATMENT OF MAMMALS THEREWITH COY, David Howard (US) 1985-06-26 EP claimed
WO-1984004916-A1 CYCLIC PENTAPEPTIDES DISPLAYING SOMATOSTATIN ANTAGONISM AND METHOD OF TREATMENT OF MAMMALS THEREWITH COY DAVID HOWARD (US) 1984-12-20 WO claimed
EP-3991752-A1 CELL-BINDING MOLECULE-TUBULYSIN DERIVATIVE CONJUGATE AND PREPARATION METHOD THEREFOR Hangzhou Dac Biotech Co., Ltd (CN) 2022-05-04 EP disclosed
US-5416073-A Replacements and derivatives of terminal amino acid residues increased milk production in cows THE ADMINSTRATORS OF THE TULANE EDUCATIONAL FUND (US) 1995-05-16 US disclosed
EP-0127899-B1 CYCLIC PENTAPEPTIDES DISPLAYING SOMATOSTATIN ANTAGONISM AND METHOD OF TREATMENT OF MAMMALS THEREWITH The Administrators of The Tulane University Educational Fund (US) 1987-10-21 EP disclosed
EP-0188214-A2 Novel growth hormone-releasing peptides and method of treating mammals therewith The Administrators of The Tulane University Educational Fund (US) 1986-07-23 EP disclosed
EP-0145768-A1 CYCLIC PENTAPEPTIDES DISPLAYING SOMATOSTATIN ANTAGONISM AND METHOD OF TREATMENT OF MAMMALS THEREWITH COY, David Howard (US) 1985-06-26 EP disclosed
EP-0136475-A2 Novel growth hormone-releasing peptides and method of treating mammals therewith The Administrators of The Tulane University Educational Fund (US) 1985-04-10 EP disclosed
US-4505897-A INCREASING RELEASE OF GROWTH HORMONE, INSULIN, AND GLUCAGON THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND (US) 1985-03-19 US disclosed
WO-1984004916-A1 CYCLIC PENTAPEPTIDES DISPLAYING SOMATOSTATIN ANTAGONISM AND METHOD OF TREATMENT OF MAMMALS THEREWITH COY DAVID HOWARD (US) 1984-12-20 WO disclosed