Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FHIT | P49789 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7427406 | 1.00 | FHIT (0.43) | FHITHDAC8HDAC1NFKB1KMT2A | |
| SCHEMBL7427640 | 0.87 | KDM4E (0.47) | NFKB1KMT2AKDM4EMAPTMEN1 | |
| SCHEMBL7427638 | 0.87 | KDM4E (0.47) | NFKB1KMT2AKDM4EMAPTMEN1 | |
| SCHEMBL7424869 | 0.86 | KDM4E (0.47) | NFKB1KMT2AKDM4EMAPTMEN1 | |
| SCHEMBL7424866 | 0.86 | KDM4E (0.47) | NFKB1KMT2AKDM4EMAPTMEN1 | |
| SCHEMBL7428940 | 0.86 | FHIT (0.46) | FHITHDAC1NFKB1KMT2AMAPT | |
| SCHEMBL7478843 | 0.85 | KDM4E (0.45) | NFKB1KMT2AKDM4EMAPTMEN1 | |
| SCHEMBL7478838 | 0.85 | KDM4E (0.45) | NFKB1KMT2AKDM4EMAPTMEN1 | |
| SCHEMBL10187521 | 0.77 | CYP1A2 (0.36) | NFKB1KMT2AKDM4EMAPTNPC1 | |
| SCHEMBL10187520 | 0.72 | CYP1A2 (0.47) | NFKB1KMT2AKDM4EMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6350885-B1 | TREATMENT OF MULTIPLE SCLEROSIS, ATHEROSCLEROTIC PLAQUE RUPTURE, AORTIC ANEURYSM, HEART FAILURE, LEFT VENTRICULAR DILATION, RESTENOSIS, PERIODONTAL DISEASE, CORNEAL ULCERATION, TREATMENT OF BURNS, DECUBITAL ULCERS, WOUND HEALING AGENT | WARNER-LAMBERT COMPANY | 2002-02-26 | — | — | US | claimed |
| WO-2000006560-A1 | TRICYCLIC HETEROAROMATICS AND THEIR DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES | WARNER-LAMBERT COMPANY (US) | 2000-02-10 | — | — | WO | claimed |
| US-6350885-B1 | TREATMENT OF MULTIPLE SCLEROSIS, ATHEROSCLEROTIC PLAQUE RUPTURE, AORTIC ANEURYSM, HEART FAILURE, LEFT VENTRICULAR DILATION, RESTENOSIS, PERIODONTAL DISEASE, CORNEAL ULCERATION, TREATMENT OF BURNS, DECUBITAL ULCERS, WOUND HEALING AGENT | WARNER-LAMBERT COMPANY | 2002-02-26 | — | — | US | disclosed |
| WO-2000006560-A1 | TRICYCLIC HETEROAROMATICS AND THEIR DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES | WARNER-LAMBERT COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |