Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5997911 | 0.90 | SMN1; SMN2 (0.69) | SMN1; SMN2LMNAALDH1A1RECQLMAPT | |
| SCHEMBL7428231 | 0.79 | SMN1; SMN2 (0.68) | SMN1; SMN2LMNARECQLMAPTHTT | |
| SCHEMBL7427432 | 0.78 | SMN1; SMN2 (0.64) | SMN1; SMN2LMNAALDH1A1RECQLMAPT | |
| SCHEMBL7431741 | 0.78 | SMN1; SMN2 (0.67) | SMN1; SMN2LMNAALDH1A1RECQLMAPT | |
| SCHEMBL24740256 | 0.78 | SMN1; SMN2 (1.00) | SMN1; SMN2LMNAALDH1A1RECQLMAPT | |
| SCHEMBL10859070 | 0.76 | SMN1; SMN2 (0.81) | SMN1; SMN2LMNAALDH1A1RECQLMAPT | |
| SCHEMBL7436139 | 0.75 | SMN1; SMN2 (0.63) | SMN1; SMN2LMNAALDH1A1RECQLMAPT | |
| SCHEMBL7431743 | 0.74 | SMN1; SMN2 (0.61) | SMN1; SMN2LMNAALDH1A1RECQLMAPT | |
| SCHEMBL277495 | 0.74 | TDP1 (0.72) | SMN1; SMN2LMNAALDH1A1RECQLMAPT | |
| SCHEMBL10605747 | 0.74 | SMN1; SMN2 (0.77) | SMN1; SMN2LMNAALDH1A1RECQLMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1155010-A1 | ACETAMIDO ACETONITRILE DERIVATIVES AS INHIBITORS OF CATHEPSIN L AND/OR CATHEPSIN S | AstraZeneca AB (SE) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000049007-A1 | ACETAMIDO ACETONITRILE DERIVATIVES AS INHIBITORS OF CATHEPSIN L AND/OR CATHEPSIN S | ASTRAZENECA AB (SE) | 2000-08-24 | — | — | WO | disclosed |