Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 0.74 |
| ▸ | HPGD | P15428 | 3/20 | 0.73 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.73 |
| ▸ | RECQL | P46063 | 2/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.62 |
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.57 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.57 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27300755 | 0.87 | SMN1; SMN2 (0.77) | SMN1; SMN2LMNAHPGDNLRP1RECQL | |
| SCHEMBL30451475 | 0.86 | SMN1; SMN2 (0.75) | SMN1; SMN2LMNAHPGDNLRP1RECQL | |
| SCHEMBL24252836 | 0.86 | SMN1; SMN2 (0.75) | SMN1; SMN2LMNAHPGDNLRP1RECQL | |
| SCHEMBL2557610 | 0.83 | SMN1; SMN2 (0.71) | SMN1; SMN2LMNAHPGDNLRP1RECQL | |
| SCHEMBL2560314 | 0.83 | SMN1; SMN2 (0.71) | SMN1; SMN2LMNAHPGDNLRP1RECQL | |
| SCHEMBL24112746 | 0.83 | TDP1 (0.72) | SMN1; SMN2LMNAHPGDRECQLTDP1 | |
| SCHEMBL27374826 | 0.83 | SMN1; SMN2 (0.71) | SMN1; SMN2LMNAHPGDNLRP1RECQL | |
| SCHEMBL8247489 | 0.82 | KMT2A (0.74) | SMN1; SMN2LMNAHPGDTDP1TSHR | |
| SCHEMBL8291109 | 0.81 | SMN1; SMN2 (0.68) | SMN1; SMN2LMNAHPGDRECQLTDP1 | |
| SCHEMBL7428231 | 0.81 | SMN1; SMN2 (0.68) | SMN1; SMN2LMNAHPGDNLRP1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230212152-A1 | INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF | Pardes Biosciences, Inc. | 2023-07-06 | — | — | US | disclosed |
| US-20230212152-A1 | INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF | Pardes Biosciences, Inc. | 2023-07-06 | — | — | US | disclosed |
| US-11524940-B1 | Inhibitors of cysteine proteases and methods of use thereof | Pardes Biosciences, Inc. (US) | 2022-12-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11524940-B1 | Inhibitors of cysteine proteases and methods of use thereof | CTRL, CTSV, CTSL | SMN1; SMN2 4032/4885LMNA 2486/4885HPGD 1608/4885 |
| US-20230212152-A1 | INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF | CTRL, CTSL, CTSV | SMN1; SMN2 3613/4885LMNA 2202/4885HPGD 1219/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.