Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7340287 | 1.00 | CA12 (0.43) | CA12CA9ALDH1A1POLBHPGD | |
| SCHEMBL7427780 | 1.00 | CA12 (0.43) | CA12CA9ALDH1A1POLBHPGD | |
| SCHEMBL7340298 | 1.00 | CA12 (0.43) | CA12CA9ALDH1A1POLBHPGD | |
| SCHEMBL7340501 | 1.00 | CA12 (0.43) | CA12CA9ALDH1A1POLBHPGD | |
| SCHEMBL7340494 | 1.00 | CA12 (0.43) | CA12CA9ALDH1A1POLBHPGD | |
| SCHEMBL1938131 | 0.88 | CA12 (0.41) | CA12CA9ALDH1A1MEN1KMT2A | |
| SCHEMBL7349416 | 0.79 | CYP2C9 (0.41) | CYP2C9CYP2C19 | |
| SCHEMBL7430706 | 0.79 | CYP2C9 (0.41) | CYP2C9CYP2C19 | |
| SCHEMBL7424298 | 0.79 | CYP2C9 (0.41) | CYP2C9CYP2C19 | |
| SCHEMBL7424303 | 0.79 | CYP2C9 (0.41) | CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0120728-A1 | Thiazine and thiazepine containing compounds | E.R. Squibb & Sons, Inc. (US) | 1984-10-03 | — | — | EP | disclosed |
| US-4460579-A | HYPOTENSIVE AGENTS, ANGIOTENSIN CONVERTING ENZYME INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1984-07-17 | — | — | US | disclosed |