Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.35 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7427690 | 1.00 | OPRK1 (0.38) | OPRK1KAT2BBAZ2BPIK3CDPDE4D | |
| SCHEMBL11050292 | 0.87 | ATM (0.31) | — | |
| SCHEMBL1322127 | 0.83 | EPHX1 (0.39) | OPRK1 | |
| SCHEMBL1319121 | 0.83 | EPHX1 (0.35) | OPRK1 | |
| SCHEMBL1319123 | 0.83 | EPHX1 (0.35) | OPRK1 | |
| SCHEMBL1322130 | 0.83 | EPHX1 (0.39) | OPRK1 | |
| SCHEMBL7271811 | 0.81 | EPHX1 (0.42) | OPRK1 | |
| SCHEMBL9433734 | 0.81 | EPHX1 (0.42) | OPRK1 | |
| SCHEMBL29883621 | 0.81 | — | — | |
| SCHEMBL29882892 | 0.77 | EPHX2 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4686217-A | HYPOTENSIVE AGENTS, CARDIOVASCULAR DISORDERS | FISONS PLC (GB) | 1987-08-11 | — | — | US | disclosed |
| US-4607041-A | CARDIOTONIC AGENTS | FISONS PLC (GB) | 1986-08-19 | — | — | US | disclosed |
| EP-0125803-A2 | Pharmaceutically active dihydropyridines | FISONS plc (GB) | 1984-11-21 | — | — | EP | disclosed |