Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 8/20 | 0.49 |
| ▸ | PDE3B | Q13370 | 6/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 4/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.39 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7430045 | 0.87 | PGR (0.50) | PGRPDE3BPDE3APDK2PDK4 | |
| SCHEMBL7432516 | 0.85 | PGR (0.49) | PGRPDE3BPDE3APDK2PDK4 | |
| SCHEMBL7426392 | 0.85 | PGR (0.49) | PGRPDE3BPDE3APDK2PDK4 | |
| SCHEMBL31117112 | 0.81 | PGR (0.45) | PGRPDE3BPDE3APDK2PDK4 | |
| SCHEMBL1874397 | 0.80 | PGR (0.55) | PGRPDE3BPDE3APDK2PDK4 | |
| SCHEMBL7380517 | 0.79 | PGR (0.34) | PGRPDK2PDK4HSD11B1 | |
| SCHEMBL5680486 | 0.78 | PGR (0.50) | PGRPDE3BPDE3APDK2PDK4 | |
| SCHEMBL7482208 | 0.77 | PGR (0.42) | PGRPDE3BPDE3APDK2PDK4 | |
| SCHEMBL31117087 | 0.76 | PGR (0.41) | PGRPDE3BPDE3APDK2PDK4 | |
| SCHEMBL7379550 | 0.76 | PGR (0.51) | PGRPDE3BPDE3APDK2PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4933336-A | Thiadiazinone, oxadiazinone and triazinone derivatives, and their use for treating acute or chronic heart disease | LABORATOIRES SOBIO S.A. (FR) | 1990-06-12 | — | — | US | disclosed |
| EP-0303418-A2 | Substituted indolones, useful in the treatment of heart or asthmatic diseases | SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES (FR) | 1989-02-15 | — | — | EP | disclosed |