Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | FABP7 | O15540 | 1/20 | 0.42 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14018477 | 0.85 | GAA (0.60) | TSHRBACE1GAAMAPTFABP7 | |
| SCHEMBL13889275 | 0.85 | GAA (0.60) | TSHRBACE1GAAMAPTFABP7 | |
| SCHEMBL3899815 | 0.85 | GAA (0.60) | TSHRBACE1GAAMAPTFABP7 | |
| Hydrochloric Acid SCHEMBL8041147 | 0.84 | GAA (0.59) | TSHRBACE1GAAMAPTFABP7 | |
| SCHEMBL11028996 | 0.83 | TSHR (0.44) | TSHRBACE1FABP7FABP5HPGD | |
| SCHEMBL16140165 | 0.82 | TNF (0.41) | GAAMAPTHPGDALDH1A1MAPK1 | |
| SCHEMBL7439144 | 0.81 | TDP1 (0.50) | TSHRBACE1 | |
| SCHEMBL28789826 | 0.79 | TSHR (0.44) | TSHRBACE1GAAMAPTFABP7 | |
| SCHEMBL6866934 | 0.77 | TSHR (0.55) | TSHRBACE1GAAFABP7FABP5 | |
| SCHEMBL4695211 | 0.77 | TSHR (0.55) | TSHRBACE1GAAFABP7FABP5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1192135-A2 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2002-04-03 | — | — | EP | disclosed |
| WO-2000076970-A2 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2000-12-21 | — | — | WO | disclosed |