Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 20/20 | 0.55 |
| ▸ | PGC | P20142 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10540148 | 0.89 | REN (0.60) | RENPGC | |
| SCHEMBL9439319 | 0.88 | REN (0.56) | RENPGC | |
| SCHEMBL7271925 | 0.84 | REN (0.57) | RENPGC | |
| SCHEMBL7386767 | 0.84 | REN (0.57) | RENPGC | |
| SCHEMBL9504686 | 0.83 | REN (0.57) | RENPGC | |
| SCHEMBL9694434 | 0.83 | REN (0.57) | RENPGC | |
| SCHEMBL9505561 | 0.83 | REN (0.57) | RENPGC | |
| SCHEMBL9183934 | 0.83 | REN (0.56) | RENPGC | |
| SCHEMBL7272695 | 0.83 | REN (0.56) | RENPGC | |
| SCHEMBL7382612 | 0.83 | REN (0.58) | RENPGC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0389898-A2 | Peptide derivatives of amino acids having a renin-inhibiting effect | F. HOFFMANN-LA ROCHE AG (CH) | 1990-10-03 | — | — | EP | claimed |
| US-5278148-A | Hypotensive agents | HOFFMANN-LA ROCHE INC. (US) | 1994-01-11 | — | — | US | disclosed |
| EP-0389898-A2 | Peptide derivatives of amino acids having a renin-inhibiting effect | F. HOFFMANN-LA ROCHE AG (CH) | 1990-10-03 | — | — | EP | disclosed |