Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 13/20 | 1.00 |
| ▸ | MMP2 | P08253 | 8/20 | 1.00 |
| ▸ | MMP9 | P14780 | 3/20 | 0.75 |
| ▸ | MMP1 | P03956 | 2/20 | 0.75 |
| ▸ | MMP3 | P08254 | 1/20 | 0.54 |
| ▸ | ADAM33 | Q9BZ11 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL7661630 | 0.96 | ADAM17 (0.92) | ADAM17MMP2MMP9MMP1MMP3 | |
| SCHEMBL7670103 | 0.90 | ADAM17 (0.91) | ADAM17MMP2MMP9MMP1 | |
| SCHEMBL7661634 | 0.89 | ADAM17 (0.81) | ADAM17MMP2MMP9MMP1 | |
| SCHEMBL7667919 | 0.89 | ADAM17 (1.00) | ADAM17MMP2MMP9MMP1 | |
| SCHEMBL7433372 | 0.89 | ADAM17 (1.00) | ADAM17MMP2MMP9MMP1 | |
| SCHEMBL7663733 | 0.88 | ADAM17 (1.00) | ADAM17MMP2MMP9MMP1 | |
| SCHEMBL7430933 | 0.87 | ADAM17 (1.00) | ADAM17MMP2MMP9MMP1 | |
| Trifluoroacetic Acid SCHEMBL7673481 | 0.86 | ADAM17 (0.83) | ADAM17MMP2MMP9MMP1 | |
| Trifluoroacetic Acid SCHEMBL7661485 | 0.85 | ADAM17 (0.91) | ADAM17MMP2MMP9MMP1 | |
| SCHEMBL7425028 | 0.85 | ADAM17 (1.00) | ADAM17MMP2MMP9MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6495548-B1 | SUCH AS 3-((2,2-DIMETHYL-1-OXOPROPYL)AMINO)-N-HYDROXY-1-(4-((2-METHYL-4 -QUINOLINYL)METHOXY)PHENYL)-2-OXO-3-PYRROLIDINE ACETAMIDE; PREVENTING UNCONTROLLED BREAKDOWN OF CONNECTIVE TISSUE | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2002-12-17 | — | — | US | claimed |
| US-6495548-B1 | SUCH AS 3-((2,2-DIMETHYL-1-OXOPROPYL)AMINO)-N-HYDROXY-1-(4-((2-METHYL-4 -QUINOLINYL)METHOXY)PHENYL)-2-OXO-3-PYRROLIDINE ACETAMIDE; PREVENTING UNCONTROLLED BREAKDOWN OF CONNECTIVE TISSUE | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2002-12-17 | — | — | US | disclosed |
| EP-1165546-A2 | NOVEL LACTAM INHIBITORS OF MATRIX METALLOPROTEINASES, TNF-ALPHA, AND AGGRECANASE | Du Pont Pharmaceuticals Company (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059285-A2 | NOVEL LACTAM INHIBITORS OF MATRIX METALLOPROTEINASES, TNF-α, AND AGGRECANASE | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-10-12 | — | — | WO | disclosed |