Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.62 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.62 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.62 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.62 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.62 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.62 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.62 |
| ▸ | HTR1A | P08908 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7436653 | 0.90 | MAPT (0.73) | MAPTADRA1AMEN1CYP1A2CYP3A4 | |
| SCHEMBL10365761 | 0.89 | MAPT (0.66) | MAPTADRA1AMEN1CYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL10471245 | 0.89 | ADRA1A (0.66) | MAPTADRA1AMEN1CYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL10366599 | 0.87 | ADRA1A (0.66) | MAPTADRA1AMEN1CYP1A2CYP3A4 | |
| SCHEMBL10366944 | 0.87 | CACNA1F (0.59) | MAPTADRA1AMEN1CYP1A2CYP3A4 | |
| SCHEMBL10366859 | 0.86 | MAPT (0.64) | MAPTADRA1AMEN1CYP1A2CYP3A4 | |
| SCHEMBL7427874 | 0.86 | MAPT (0.66) | MAPTADRA1AMEN1CYP1A2CYP3A4 | |
| SCHEMBL10364904 | 0.86 | MAPT (0.66) | MAPTADRA1AMEN1CYP1A2CYP3A4 | |
| SCHEMBL10889767 | 0.86 | MAPT (0.71) | MAPTADRA1AMEN1CYP1A2CYP3A4 | |
| SCHEMBL10417327 | 0.85 | MEN1 (0.67) | MAPTADRA1AMEN1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0097821-A2 | Dihydropyridines with an antagonistic activity to calcium, process for their preparation, and pharmaceutical compositions containing them | Pierrel S.p.A. (IT) | 1984-01-11 | — | — | EP | claimed |
| EP-0094159-B1 | DIHYDROPYRIDINE DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1990-03-14 | — | — | EP | disclosed |
| US-4892875-A | HYPOTENSIVE, RENAL VASODILATION | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1990-01-09 | — | — | US | disclosed |
| EP-0094159-A1 | Dihydropyridine derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1983-11-16 | — | — | EP | disclosed |