SCHEMBL7428773

SCHEMBL7428773

CCCCCC#CCOc1ccc(S(=O)(=O)C2(C(=O)ONCc3ccc(Br)cc3)CCNCC2)cc1

nearest known ligand 0.64

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
ADAM17 P78536 18/20 0.64
MMP13 P45452 14/20 0.55
MMP9 P14780 11/20 0.47
MMP1 P03956 9/20 0.47
MMP2 P08253 1/20 0.43
MMP3 P08254 1/20 0.40
MMP10 P09238 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7427544 0.92 ADAM17 (0.60) ADAM17MMP13MMP9MMP1MMP2
SCHEMBL7421888 0.85 ADAM17 (0.58) ADAM17MMP13MMP9MMP1MMP2
SCHEMBL7423131 0.85 ADAM17 (0.53) ADAM17MMP13MMP9MMP1MMP2
SCHEMBL6870501 0.84 ADAM17 (0.56) ADAM17MMP13MMP9MMP1MMP2
SCHEMBL7437127 0.83 ADAM17 (0.67) ADAM17MMP13MMP9MMP1MMP2
SCHEMBL7423765 0.80 ADAM17 (0.67) ADAM17MMP13MMP9MMP1MMP2
SCHEMBL6263654 0.78 ADAM17 (0.82) ADAM17MMP13MMP9MMP1
SCHEMBL4026606 0.78 ADAM17 (0.82) ADAM17MMP13MMP9MMP1
SCHEMBL6262973 0.78 ADAM17 (1.00) ADAM17MMP13MMP9MMP1
SCHEMBL6261771 0.77 ADAM17 (0.86) ADAM17MMP13MMP9MMP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1147085-A1 ALKYNYL CONTAINING HYDROXAMIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS / TNF-ALPHA CONVERTING ENZYME (TACE) INHIBITORS American Cyanamid Company (US) 2001-10-24 EP claimed
WO-2000044723-A1 ALKYNYL CONTAINING HYDROXAMIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS/TNF-ALPHA CONVERTING ENZYME (TACE) INHIBITORS AMERICAN CYANAMID COMPANY (US) 2000-08-03 WO claimed
EP-1147085-A1 ALKYNYL CONTAINING HYDROXAMIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS / TNF-ALPHA CONVERTING ENZYME (TACE) INHIBITORS American Cyanamid Company (US) 2001-10-24 EP disclosed
WO-2000044723-A1 ALKYNYL CONTAINING HYDROXAMIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS/TNF-ALPHA CONVERTING ENZYME (TACE) INHIBITORS AMERICAN CYANAMID COMPANY (US) 2000-08-03 WO disclosed