Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 5/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.47 |
| ▸ | KDR | P35968 | 5/20 | 0.47 |
| ▸ | RET | P07949 | 3/20 | 0.47 |
| ▸ | FLT3 | P36888 | 3/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.47 |
| ▸ | FLT1 | P17948 | 3/20 | 0.47 |
| ▸ | AURKA | O14965 | 2/20 | 0.47 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.47 |
| ▸ | STK3 | Q13188 | 2/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.47 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.47 |
| ▸ | GAK | O14976 | 1/20 | 0.47 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.47 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.47 |
| ▸ | LATS1 | O95835 | 1/20 | 0.47 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.47 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.47 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.47 |
| ▸ | STK4 | Q13043 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7422251 | 0.85 | PDGFRB (0.67) | PDGFRBFGFR1KDRRETFLT3 | |
| SCHEMBL5999627 | 0.82 | PDGFRB (0.73) | PDGFRBFGFR1KDRRETFLT3 | |
| SCHEMBL5999628 | 0.82 | PDGFRB (0.73) | PDGFRBFGFR1KDRRETFLT3 | |
| SCHEMBL20338611 | 0.75 | FGFR1 (0.70) | PDGFRBFGFR1KDRRETFLT3 | |
| SCHEMBL6412297 | 0.73 | PDGFRB (0.74) | PDGFRBFGFR1KDRRETFLT3 | |
| SCHEMBL6412300 | 0.73 | PDGFRB (0.74) | PDGFRBFGFR1KDRRETFLT3 | |
| SCHEMBL7476948 | 0.73 | AURKA (0.51) | PDGFRBFGFR1KDRRETFLT3 | |
| SCHEMBL7476554 | 0.73 | AURKA (0.51) | PDGFRBFGFR1KDRRETFLT3 | |
| SCHEMBL7421627 | 0.72 | KDR (0.48) | PDGFRBFGFR1KDRRETFLT3 | |
| SCHEMBL8413459 | 0.71 | PDGFRB (0.70) | PDGFRBFGFR1KDRRETFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0769947-A4 | INDOLINONE COMPOUNDS FOR THE TREATMENT OF DISEASE | SUGEN INC (US) | 1998-09-30 | — | — | EP | disclosed |
| EP-0769947-A1 | INDOLINONE COMPOUNDS FOR THE TREATMENT OF DISEASE | Sugen, Inc. (US) | 1997-05-02 | — | — | EP | disclosed |
| WO-1996040116-A1 | INDOLINONE COMPOUNDS FOR THE TREATMENT OF DISEASE | SUGEN, INC. (US) | 1996-12-19 | — | — | WO | disclosed |