Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 4/20 | 0.67 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.50 |
| ▸ | KDR | P35968 | 7/20 | 0.47 |
| ▸ | RET | P07949 | 5/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.46 |
| ▸ | FLT3 | P36888 | 5/20 | 0.46 |
| ▸ | FLT1 | P17948 | 4/20 | 0.46 |
| ▸ | AURKA | O14965 | 3/20 | 0.46 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.46 |
| ▸ | STK3 | Q13188 | 3/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.46 |
| ▸ | CSF1R | P07333 | 3/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.46 |
| ▸ | FLT4 | P35916 | 3/20 | 0.46 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.46 |
| ▸ | ABL1 | P00519 | 2/20 | 0.46 |
| ▸ | PLK4 | O00444 | 2/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7428873 | 0.85 | PDGFRB (0.52) | PDGFRBALKKDRRETFGFR1 | |
| SCHEMBL6000845 | 0.80 | PDGFRB (1.00) | PDGFRBALKKDRRETFGFR1 | |
| SCHEMBL6000848 | 0.80 | PDGFRB (1.00) | PDGFRBALKKDRRETFGFR1 | |
| SCHEMBL7420844 | 0.80 | KDR (0.58) | PDGFRBALKKDRRETFGFR1 | |
| SCHEMBL20338611 | 0.78 | FGFR1 (0.70) | PDGFRBALKKDRRETFGFR1 | |
| SCHEMBL7421627 | 0.76 | KDR (0.48) | PDGFRBALKKDRRETFGFR1 | |
| SCHEMBL5728018 | 0.75 | PDGFRB (0.81) | PDGFRBALKKDRRETFGFR1 | |
| SCHEMBL5728020 | 0.75 | PDGFRB (0.81) | PDGFRBALKKDRRETFGFR1 | |
| SCHEMBL1444503 | 0.71 | MAPT (0.54) | PDGFRBALKKDRRETFLT3 | |
| SCHEMBL1444136 | 0.71 | MAPT (0.54) | PDGFRBALKKDRRETFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0769947-A4 | INDOLINONE COMPOUNDS FOR THE TREATMENT OF DISEASE | SUGEN INC (US) | 1998-09-30 | — | — | EP | disclosed |
| EP-0769947-A1 | INDOLINONE COMPOUNDS FOR THE TREATMENT OF DISEASE | Sugen, Inc. (US) | 1997-05-02 | — | — | EP | disclosed |
| WO-1996040116-A1 | INDOLINONE COMPOUNDS FOR THE TREATMENT OF DISEASE | SUGEN, INC. (US) | 1996-12-19 | — | — | WO | disclosed |