SCHEMBL7429111

SCHEMBL7429111

COc1cc(CC(=O)N2CCCN(C(=O)C(C)(C)CC(=O)O)CC2)ccc1NC(=O)Nc1ccccc1C

nearest known ligand 0.59

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ITGA4 P13612 19/20 0.59
ITGB1 P05556 17/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7420922 0.92 ITGA4 (0.52) ITGA4ITGB1
SCHEMBL7543313 0.89 ITGA4 (0.57) ITGA4ITGB1
SCHEMBL7424439 0.88 ITGA4 (0.63) ITGA4ITGB1
SCHEMBL7423191 0.87 ITGA4 (0.58) ITGA4ITGB1
SCHEMBL7426829 0.87 ITGA4 (0.63) ITGA4ITGB1
SCHEMBL7535332 0.85 ITGA4 (0.57) ITGA4ITGB1
SCHEMBL7429677 0.85 ITGA4 (0.61) ITGA4ITGB1
SCHEMBL7420275 0.84 ITGA4 (0.60) ITGA4ITGB1
SCHEMBL7422719 0.83 ITGA4 (0.59) ITGA4ITGB1
SCHEMBL7425736 0.83 ITGA4 (0.59) ITGA4ITGB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1999054321-A1 SUBSTITUTED DIAMINES AND THEIR USE AS CELL ADHESION INHIBITORS AVENTIS PHARMA LIMITED (GB) 1999-10-28 WO disclosed