Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 3/20 | 0.65 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.65 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.65 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.65 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.65 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.65 |
| ▸ | REN | P00797 | 15/20 | 0.64 |
| ▸ | BACE1 | P56817 | 1/20 | 0.48 |
| ▸ | MMP3 | P08254 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7433520 | 0.86 | REN (0.60) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7438173 | 0.84 | PSEN1 (0.63) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7429175 | 0.83 | REN (0.63) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7433079 | 0.82 | REN (0.62) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7433526 | 0.82 | REN (0.61) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7432310 | 0.80 | REN (0.59) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL9574958 | 0.80 | REN (0.59) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7431784 | 0.80 | REN (0.61) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7438083 | 0.79 | REN (0.58) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7431648 | 0.79 | REN (0.58) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0331105-A2 | 1,2-Hydroxy phosphonates and derivatives thereof | E.R. Squibb & Sons, Inc. (US) | 1989-09-06 | — | — | EP | claimed |
| US-5217958-A | Hypotensive agents | E. R. SQUIBB & SONS, INC. (US) | 1993-06-08 | — | — | US | disclosed |
| WO-1989007940-A1 | 1,2-HYDROXY PHOSPHONATES AND DERIVATIVES THEREOF | E.R. SQUIBB & SONS, INC. (US) | 1989-09-08 | — | — | WO | disclosed |
| EP-0331105-A2 | 1,2-Hydroxy phosphonates and derivatives thereof | E.R. Squibb & Sons, Inc. (US) | 1989-09-06 | — | — | EP | disclosed |