Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | REN | P00797 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7436111 | 0.90 | CASP1 (0.49) | CASP1TP53 | |
| SCHEMBL7429733 | 0.89 | CASP1 (0.42) | CASP1RENTP53 | |
| SCHEMBL7432245 | 0.87 | CASP1 (0.42) | CASP1RENBACE1 | |
| SCHEMBL7427023 | 0.86 | CASP1 (0.41) | CASP1RENBACE1 | |
| SCHEMBL7436591 | 0.85 | CASP1 (0.41) | CASP1RENBACE1 | |
| SCHEMBL7440398 | 0.84 | CASP1 (0.52) | CASP1TP53MEN1KMT2A | |
| SCHEMBL7439311 | 0.84 | CASP1 (0.48) | CASP1NPC1HPGDRAB9AL3MBTL1 | |
| SCHEMBL7432201 | 0.83 | CASP1 (0.46) | CASP1HPGDTP53 | |
| SCHEMBL7441347 | 0.82 | CYP1A2 (0.48) | RENTP53BACE1MEN1KMT2A | |
| SCHEMBL7436443 | 0.82 | CASP1 (0.46) | CASP1NPC1HPGDRAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5710153-A | INTERLEUKIN CONVERTING ENZYME INHIBITORS | ONO PHRAMACEUTICAL CO., LTD. (JP) | 1998-01-20 | — | — | US | disclosed |
| EP-0761680-A2 | Tetrazole compounds having Interleukin-1beta converting enzyme inhibitory activity | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-03-12 | — | — | EP | disclosed |