Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 10/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 3/20 | 0.41 |
| ▸ | APP | P05067 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6212918 | 0.91 | ACHE (0.45) | PDE5APDE10AACHEAPP | |
| SCHEMBL6762884 | 0.89 | ACHE (0.45) | PDE5APDE10AACHE | |
| SCHEMBL6213972 | 0.88 | ACHE (0.44) | PDE5APDE10AACHE | |
| SCHEMBL6213796 | 0.88 | ACHE (0.43) | PDE5APDE10AACHE | |
| SCHEMBL6852711 | 0.86 | ACHE (0.51) | PDE5APDE10AACHEAPP | |
| SCHEMBL7431899 | 0.86 | ACHE (0.47) | PDE5APDE10AACHEAPP | |
| SCHEMBL6216647 | 0.85 | PDE5A (0.44) | PDE5APDE10AACHE | |
| SCHEMBL6213943 | 0.85 | PDE5A (0.46) | PDE5APDE10AACHE | |
| SCHEMBL6213950 | 0.84 | ACHE (0.49) | PDE5APDE10AACHEAPP | |
| SCHEMBL6763361 | 0.83 | PDE5A (0.43) | PDE5APDE10AACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212329-A2 | AMINE DERIVATIVES OF BENZO[4,5]THIENO[2,3-D]PYRIMIDINE | MERCK PATENT GmbH (DE) | 2002-06-12 | — | — | EP | claimed |
| WO-2001021620-A2 | AMINE DERIVATIVES OF BENZO-4,5-THIENO-2,3-D PYRIMIDINES | MERCK PATENT GMBH (DE) | 2001-03-29 | — | — | WO | claimed |