Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 8/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8669985 | 1.00 | ELANE (0.48) | ELANEHSD17B10TDP1KDM4ETSHR | |
| SCHEMBL9619966 | 1.00 | ELANE (0.48) | ELANEHSD17B10TDP1KDM4ETSHR | |
| SCHEMBL9619969 | 1.00 | ELANE (0.48) | ELANEHSD17B10TDP1KDM4ETSHR | |
| SCHEMBL7429479 | 1.00 | ELANE (0.48) | ELANEHSD17B10TDP1KDM4ETSHR | |
| SCHEMBL8667999 | 1.00 | ELANE (0.48) | ELANEHSD17B10TDP1KDM4ETSHR | |
| SCHEMBL8668001 | 1.00 | ELANE (0.48) | ELANEHSD17B10TDP1KDM4ETSHR | |
| SCHEMBL8669982 | 1.00 | ELANE (0.48) | ELANEHSD17B10TDP1KDM4ETSHR | |
| SCHEMBL7279284 | 1.00 | ELANE (0.48) | ELANEHSD17B10TDP1KDM4ETSHR | |
| Hydrochloric Acid SCHEMBL10932577 | 0.99 | ELANE (0.47) | ELANEHSD17B10TDP1KDM4ETSHR | |
| Hydrochloric Acid SCHEMBL10932585 | 0.99 | ELANE (0.47) | ELANEHSD17B10TDP1KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5132301-A | Substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents | MERCK & CO., INC. (US) | 1992-07-21 | — | — | US | disclosed |
| EP-0267723-A2 | New substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents | MERCK & CO. INC. (US) | 1988-05-18 | — | — | EP | disclosed |
| US-4637999-A | PROTEASE INHIBITORS | MERCK & CO., INC. (US) | 1987-01-20 | — | — | US | disclosed |
| US-4547371-A | Substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents | MERCK & CO., INC. (US) | 1985-10-15 | — | — | US | disclosed |