Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11752297 | 0.82 | SIRT2 (0.56) | SIRT2RAB9ANPC1TSHRCYP1A2 | |
| SCHEMBL4952678 | 0.82 | SIRT2 (0.56) | SIRT2RAB9ANPC1TSHRCYP1A2 | |
| SCHEMBL14125304 | 0.81 | SIRT2 (0.50) | SIRT2RAB9ANPC1TSHRSMN1; SMN2 | |
| SCHEMBL2216539 | 0.81 | SIRT2 (0.55) | SIRT2RAB9ANPC1TSHRCYP1A2 | |
| SCHEMBL17662411 | 0.77 | HDAC3 (0.51) | SIRT2RAB9ANPC1TSHRSMN1; SMN2 | |
| SCHEMBL3978075 | 0.77 | TSHR (0.45) | SIRT2RAB9AL3MBTL1NPC1TSHR | |
| SCHEMBL15701333 | 0.77 | HDAC3 (0.56) | SIRT2RAB9ANPC1TSHRSMN1; SMN2 | |
| SCHEMBL6552751 | 0.76 | HPSE (0.57) | SIRT2RAB9ANPC1SMN1; SMN2HDAC3 | |
| SCHEMBL15159809 | 0.75 | SIRT2 (0.44) | SIRT2RAB9ANPC1TSHRSMN1; SMN2 | |
| SCHEMBL3148356 | 0.75 | HPSE (0.59) | SIRT2RAB9ANPC1SMN1; SMN2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999048911-A1 | MONOBACTAM ENZYME INHIBITORS | NAEJA PHARMACEUTICAL INC. (GB) | 1999-09-30 | — | — | WO | disclosed |