Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7424264 | 0.87 | MEN1 (0.52) | SMN1; SMN2HSD17B10ADORA2AALDH1A1CYP3A4 | |
| SCHEMBL7395069 | 0.81 | ALDH1A1 (0.42) | ALDH1A1CYP3A4SLC6A3MEN1KMT2A | |
| SCHEMBL27900691 | 0.80 | CYP3A4 (0.56) | CYP3A4 | |
| SCHEMBL1389204 | 0.80 | CYP3A4 (0.56) | CYP3A4 | |
| SCHEMBL7178746 | 0.80 | CYP3A4 (0.48) | CYP3A4 | |
| SCHEMBL7391613 | 0.80 | CYP3A4 (0.56) | CYP3A4 | |
| SCHEMBL7178744 | 0.80 | CYP3A4 (0.48) | CYP3A4 | |
| SCHEMBL7527628 | 0.79 | CYP3A4 (0.55) | CYP3A4 | |
| SCHEMBL7188807 | 0.78 | CYP3A4 (0.44) | CYP3A4 | |
| SCHEMBL7178210 | 0.78 | CYP3A4 (0.43) | CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008103949-A1 | MODULATORS OF PHARMACOKINETIC PROPERTIES OF THERAPEUTICS | GILEAD SCIENCES, INC. (US) | 2008-08-28 | — | — | WO | disclosed |
| EP-1077977-A1 | RETROVIRAL PROTEASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999059994-A1 | RETROVIRAL PROTEASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1999-11-25 | — | — | WO | disclosed |