SCHEMBL7429889

SCHEMBL7429889

Cc1ccccc1-c1ccccc1C(=O)Cl

nearest known ligand 0.48

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MYC P01106 1/20 0.48
ALDH1A1 P00352 3/20 0.47
ALOX15 P16050 1/20 0.47
KMT2A Q03164 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
MCL1 Q07820 1/20 0.42
TACR1 P25103 1/20 0.41
FTO Q9C0B1 1/20 0.41
HPGD P15428 3/20 0.41
KDM4E B2RXH2 1/20 0.39
HSD17B10 Q99714 1/20 0.39
PLA2G7 Q13093 2/20 0.39
ERCC5 P28715 1/20 0.39
FEN1 P39748 1/20 0.39
NPC1 O15118 1/20 0.38
RAB9A P51151 1/20 0.38
BRD4 O60885 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9712532 0.98 MYC (0.47) MYCALDH1A1ALOX15KMT2AL3MBTL1
SCHEMBL29688494 0.87 ALDH1A1 (0.58) MYCALDH1A1ALOX15KMT2AL3MBTL1
SCHEMBL993303 0.87 ALDH1A1 (0.58) MYCALDH1A1ALOX15KMT2AL3MBTL1
SCHEMBL7430270 0.86 MYC (0.49) MYCALDH1A1ALOX15KMT2AL3MBTL1
Hydrochloric Acid SCHEMBL9712514 0.84 MYC (0.41) MYCALDH1A1ALOX15KMT2AL3MBTL1
Hydrochloric Acid SCHEMBL9712422 0.83 MYC (0.40) MYCALDH1A1ALOX15KMT2AL3MBTL1
SCHEMBL29677294 0.82 ALDH1A1 (0.54) MYCALDH1A1ALOX15KMT2AHPGD
SCHEMBL93382 0.82 ALDH1A1 (0.54) MYCALDH1A1ALOX15KMT2AHPGD
SCHEMBL9531784 0.82 MYC (0.47) MYCALDH1A1ALOX15L3MBTL1MCL1
SCHEMBL5702272 0.81 ALDH1A1 (0.41) MYCALDH1A1ALOX15KMT2AL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1430599-A Phenylglycine derivatives HOFFMANN LA ROCHE (CH) 2003-07-16 CN disclosed
EP-1183239-A1 AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR G.D. SEARLE & CO. (US) 2002-03-06 EP disclosed
WO-2000069821-A1 AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR G.D. SEARLE & CO. (US) 2000-11-23 WO disclosed
US-4785019-A ANTIGROWTH AGENTS CHEVRON RESEARCH COMPANY (US) 1988-11-15 US disclosed