Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.37 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.36 |
| ▸ | RECQL | P46063 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 2/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3982938 | 0.83 | PTPN1 (0.46) | PTPN1KEAP1PTPN2PTPN6POLB | |
| SCHEMBL1053659 | 0.81 | IKBKB (0.41) | PTPN1KEAP1PTPN2PTPN6POLB | |
| SCHEMBL28761620 | 0.74 | ALDH1A1 (0.42) | PTPN1KEAP1PTPN2PTPN6POLB | |
| SCHEMBL3981479 | 0.74 | ALDH1A1 (0.56) | POLBKMT2AHSD17B10MEN1ALDH1A1 | |
| SCHEMBL16147858 | 0.68 | TAAR1 (0.52) | KEAP1POLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL3060862 | 0.67 | — | — | |
| SCHEMBL29695129 | 0.67 | ALDH1A1 (0.44) | POLBKMT2AHSD17B10MEN1ALDH1A1 | |
| SCHEMBL4441896 | 0.67 | ALDH1A1 (0.37) | POLBKMT2AMEN1ALDH1A1TDP1 | |
| SCHEMBL6670434 | 0.67 | ALDH1A1 (0.45) | PTPN1POLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL3325853 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183239-A1 | AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | G.D. SEARLE & CO. (US) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000069821-A1 | AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | G.D. SEARLE & CO. (US) | 2000-11-23 | — | — | WO | disclosed |