Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 4/20 | 0.77 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 4/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7329995 | 0.92 | SRD5A1 (0.69) | SRD5A1MAPTALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL6820047 | 0.87 | SRD5A1 (1.00) | SRD5A1MAPTALDH1A1TP53HPGD | |
| SCHEMBL24893220 | 0.77 | SRD5A1 (0.61) | SRD5A1MAPTALDH1A1TP53HPGD | |
| SCHEMBL19117986 | 0.73 | SRD5A1 (0.56) | SRD5A1ALDH1A1TP53NPC1RAB9A | |
| SCHEMBL24893200 | 0.72 | SRD5A1 (0.55) | SRD5A1ALDH1A1TP53SMN1; SMN2TSHR | |
| SCHEMBL26091968 | 0.70 | MAPT (0.55) | SRD5A1MAPTALDH1A1HPGDTSHR | |
| SCHEMBL24893251 | 0.69 | SRD5A1 (0.51) | SRD5A1MAPTALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL24893246 | 0.69 | SRD5A1 (0.51) | SRD5A1MAPTALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL27787701 | 0.68 | SRD5A1 (0.50) | SRD5A1MAPTALDH1A1TP53NPC1 | |
| SCHEMBL3905172 | 0.67 | ALDH1A1 (0.53) | SRD5A1MAPTALDH1A1TP53NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4997831-A | Antagonists of 5-hydroxytryptamine receptors | GLAXO GROUP LIMITED (GB) | 1991-03-05 | — | — | US | disclosed |
| EP-0357417-A1 | Lactam derivatives | GLAXO GROUP LIMITED (GB) | 1990-03-07 | — | — | EP | disclosed |