Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 18/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL744898 | 0.93 | LTA4H (0.52) | LTA4HEPHX2KCNH2 | |
| SCHEMBL742274 | 0.90 | LTA4H (0.48) | LTA4HEPHX2KCNH2 | |
| SCHEMBL745544 | 0.87 | LTA4H (0.51) | LTA4HEPHX2KCNH2 | |
| Hydrochloric Acid SCHEMBL3746254 | 0.86 | LTA4H (0.50) | LTA4HEPHX2KCNH2 | |
| SCHEMBL15252243 | 0.85 | LTA4H (0.47) | LTA4HEPHX2KCNH2 | |
| SCHEMBL743395 | 0.84 | LTA4H (0.71) | LTA4HEPHX2KCNH2 | |
| SCHEMBL744389 | 0.84 | LTA4H (0.59) | LTA4HEPHX2KCNH2 | |
| SCHEMBL15252290 | 0.83 | LTA4H (0.59) | LTA4HEPHX2KCNH2 | |
| SCHEMBL743354 | 0.83 | LTA4H (0.59) | LTA4HEPHX2KCNH2 | |
| SCHEMBL15252064 | 0.83 | LTA4H (0.53) | LTA4HEPHX2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430019-A1 | COMPOUNDS WITH TWO FUSED BICYCLIC HETEROARYL MOIETIES AS MODULATORS OF LEUKOTRIENE A4 HYDROLASE | Janssen Pharmaceutica, N.V. (BE) | 2012-03-21 | — | — | EP | disclosed |
| WO-2010132599-A1 | COMPOUNDS WITH TWO FUSED BICYCLIC HETEROARYL MOIETIES AS MODULATORS OF LEUKOTRIENE A4 HYDROLASE | JANSSEN PHARMACEUTICA NV (BE) | 2010-11-18 | — | — | WO | disclosed |