Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.37 |
| ▸ | HRH2 | P25021 | 1/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.32 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.32 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10872427 | 0.96 | HRH2 (0.39) | HRH4HRH3HRH2 | |
| Hydrochloric Acid SCHEMBL10874377 | 0.96 | HRH2 (0.39) | HRH4HRH3HRH2 | |
| Hydrochloric Acid SCHEMBL10872130 | 0.95 | HRH2 (0.39) | HRH4HRH3HRH2 | |
| SCHEMBL7429764 | 0.86 | HRH4 (0.33) | HRH4HRH3HRH2GRIN2DGRIN3B | |
| SCHEMBL11039962 | 0.83 | SIGMAR1 (0.41) | HRH4HRH3HRH2GRIN2DGRIN3B | |
| SCHEMBL11039968 | 0.83 | SIGMAR1 (0.41) | HRH4HRH3HRH2GRIN2DGRIN3B | |
| SCHEMBL10872426 | 0.83 | GBA1 (0.30) | — | |
| Hydrochloric Acid SCHEMBL11083350 | 0.82 | SIGMAR1 (0.40) | HRH4HRH3HRH2GRIN2DGRIN3B | |
| SCHEMBL10378421 | 0.81 | SCN5A (0.46) | HRH4HRH3HRH2 | |
| SCHEMBL11039972 | 0.79 | GRIN2D (0.41) | HRH4HRH3HRH2GRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0448765-B1 | Use of guanidine derivatives for the manufacture of a medicament with NPY-antagonistic activity | HEUMANN PHARMA GMBH & CO (DE) | 1994-08-17 | — | — | EP | claimed |
| EP-0448765-A1 | Use of guanidine derivatives for the manufacture of a medicament with NPY-antagonistic activity | HEUMANN PHARMA GMBH & CO (DE) | 1991-10-02 | — | — | EP | claimed |
| EP-0448765-B1 | Use of guanidine derivatives for the manufacture of a medicament with NPY-antagonistic activity | HEUMANN PHARMA GMBH & CO (DE) | 1994-08-17 | — | — | EP | disclosed |
| EP-0448765-A1 | Use of guanidine derivatives for the manufacture of a medicament with NPY-antagonistic activity | HEUMANN PHARMA GMBH & CO (DE) | 1991-10-02 | — | — | EP | disclosed |