Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 6/20 | 0.40 |
| ▸ | ACE | P12821 | 5/20 | 0.35 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.35 |
| ▸ | F2 | P00734 | 5/20 | 0.34 |
| ▸ | FAP | Q12884 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7433766 | 0.97 | DPP4 (0.42) | DPP4ACEACE2F2 | |
| SCHEMBL7444009 | 0.90 | DPP4 (0.42) | DPP4ACEACE2F2FAP | |
| Hydrochloric Acid SCHEMBL7415872 | 0.89 | DPP4 (0.41) | DPP4ACEACE2F2FAP | |
| Sulfuric Acid SCHEMBL7436108 | 0.89 | ACE (0.37) | DPP4ACEACE2F2FAP | |
| Sulfuric Acid SCHEMBL9554342 | 0.88 | DPP4 (0.37) | DPP4ACEACE2F2 | |
| SCHEMBL9218974 | 0.88 | DPP4 (0.44) | DPP4ACEACE2F2 | |
| SCHEMBL7106838 | 0.86 | ACE (0.39) | DPP4ACEACE2F2FAP | |
| SCHEMBL9221310 | 0.81 | DPP4 (0.38) | DPP4ACEF2FAP | |
| SCHEMBL9226805 | 0.79 | DPP4 (0.38) | DPP4ACEF2FAP | |
| SCHEMBL9223278 | 0.79 | DPP4 (0.33) | DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0837071-A1 | Tripeptide antithrombotic agents | ELI LILLY AND COMPANY (US) | 1998-04-22 | — | — | EP | disclosed |
| EP-0685489-A2 | Tripeptide antithrombotic agents | ELI LILLY AND COMPANY (US) | 1995-12-06 | — | — | EP | disclosed |
| EP-0684258-A2 | Tripeptide antithrombotic agents | ELI LILLY AND COMPANY (US) | 1995-11-29 | — | — | EP | disclosed |
| US-5430023-A | Tripeptide antithrombotic agents | ELI LILLY AND COMPANY (US) | 1995-07-04 | — | — | US | disclosed |
| EP-0479489-A2 | Tripeptide antithrombotic agents | ELI LILLY AND COMPANY (US) | 1992-04-08 | — | — | EP | disclosed |