Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 14/20 | 0.56 |
| ▸ | MMP2 | P08253 | 9/20 | 0.52 |
| ▸ | MMP9 | P14780 | 4/20 | 0.52 |
| ▸ | MMP1 | P03956 | 2/20 | 0.49 |
| ▸ | MMP3 | P08254 | 2/20 | 0.47 |
| ▸ | MMP7 | P09237 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | MMP14 | P50281 | 1/20 | 0.47 |
| ▸ | MMP15 | P51511 | 1/20 | 0.47 |
| ▸ | MMP16 | P51512 | 1/20 | 0.47 |
| ▸ | ADAM33 | Q9BZ11 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL7430366 | 0.90 | ADAM17 (0.59) | ADAM17MMP2MMP9MMP1MMP3 | |
| SCHEMBL7427259 | 0.84 | ADAM17 (0.65) | ADAM17MMP2MMP9MMP1MMP3 | |
| Trifluoroacetic Acid SCHEMBL6626825 | 0.78 | ADAM17 (0.62) | ADAM17MMP2MMP9MMP1MMP3 | |
| Trifluoroacetic Acid SCHEMBL7669866 | 0.77 | ADAM17 (0.91) | ADAM17MMP2MMP9MMP1 | |
| Trifluoroacetic Acid SCHEMBL7661679 | 0.76 | ADAM17 (0.92) | ADAM17MMP2MMP9MMP1 | |
| SCHEMBL7427250 | 0.74 | ADAM17 (0.67) | ADAM17MMP2MMP9MMP1MMP3 | |
| Trifluoroacetic Acid SCHEMBL7665967 | 0.74 | ADAM17 (0.91) | ADAM17MMP2MMP9MMP1 | |
| SCHEMBL7425875 | 0.74 | ADAM17 (0.68) | ADAM17MMP2MMP9MMP1MMP3 | |
| SCHEMBL7428024 | 0.74 | ADAM17 (0.68) | ADAM17MMP2MMP9MMP1MMP3 | |
| Trifluoroacetic Acid SCHEMBL7673481 | 0.73 | ADAM17 (0.83) | ADAM17MMP2MMP9MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165546-A2 | NOVEL LACTAM INHIBITORS OF MATRIX METALLOPROTEINASES, TNF-ALPHA, AND AGGRECANASE | Du Pont Pharmaceuticals Company (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059285-A2 | NOVEL LACTAM INHIBITORS OF MATRIX METALLOPROTEINASES, TNF-α, AND AGGRECANASE | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-10-12 | — | — | WO | disclosed |