Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7433134 | 1.00 | MAPT (0.45) | MAPTNPSR1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL4539659 | 0.83 | MAPT (0.46) | MAPTNPSR1ALDH1A1LMNAKMT2A | |
| SCHEMBL4539662 | 0.83 | MAPT (0.46) | MAPTNPSR1ALDH1A1LMNAKMT2A | |
| SCHEMBL10387257 | 0.83 | MAPT (0.46) | MAPTNPSR1ALDH1A1LMNAKMT2A | |
| SCHEMBL11199388 | 0.78 | NPSR1 (0.42) | MAPTNPSR1ALDH1A1LMNAKMT2A | |
| SCHEMBL9760205 | 0.78 | MAPT (0.45) | MAPTNPSR1ALDH1A1LMNAKMT2A | |
| SCHEMBL9760210 | 0.78 | MAPT (0.45) | MAPTNPSR1ALDH1A1LMNAKMT2A | |
| SCHEMBL4732469 | 0.76 | KMT2A (0.53) | MAPTNPSR1ALDH1A1LMNAKMT2A | |
| SCHEMBL4732467 | 0.76 | KMT2A (0.53) | MAPTNPSR1ALDH1A1LMNAKMT2A | |
| SCHEMBL3194980 | 0.74 | MAPT (0.55) | MAPTNPSR1CYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4607041-A | CARDIOTONIC AGENTS | FISONS PLC (GB) | 1986-08-19 | — | — | US | disclosed |
| EP-0125803-A2 | Pharmaceutically active dihydropyridines | FISONS plc (GB) | 1984-11-21 | — | — | EP | disclosed |