Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.36 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9760210 | 1.00 | MAPT (0.45) | MAPTNPSR1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL4539659 | 0.83 | MAPT (0.46) | MAPTNPSR1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL4539662 | 0.83 | MAPT (0.46) | MAPTNPSR1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL10387257 | 0.83 | MAPT (0.46) | MAPTNPSR1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL7433136 | 0.78 | MAPT (0.45) | MAPTNPSR1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL11199388 | 0.78 | NPSR1 (0.42) | MAPTNPSR1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL7433134 | 0.78 | MAPT (0.45) | MAPTNPSR1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL4776452 | 0.76 | CYP1A2 (0.45) | MAPTSMN1; SMN2PTGS2HPGDNPC1 | |
| SCHEMBL4776457 | 0.76 | CYP1A2 (0.45) | MAPTSMN1; SMN2PTGS2HPGDNPC1 | |
| SCHEMBL7322381 | 0.75 | SMN1; SMN2 (0.38) | MAPTNPSR1SMN1; SMN2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5026863-A | Medicinal products in racemic or enantiomorph form; calcium channel blockers. hypotensive agents, cardiovascular disorders | ADIR ET COMPAGNIE (FR) | 1991-06-25 | — | — | US | disclosed |
| US-4983740-A | Multistep; from 2- 2-/2-chloroethoxy/ethoxy!ethanol and potassium phthalimide | ADIR ET COMPAGNIE (FR) | 1991-01-08 | — | — | US | disclosed |
| US-4870091-A | CALCIUM CHANNEL BLOCKERS | ADIR ET CIE (FR) | 1989-09-26 | — | — | US | disclosed |