Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1C | Q13936 | 3/20 | 0.67 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.67 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.67 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9765688 | 0.92 | CACNA1C (0.74) | CACNA1CCACNA1FCACNA1DCACNA1SCYP1A2 | |
| SCHEMBL7426471 | 0.90 | CACNA1C (0.55) | CACNA1CCACNA1FCACNA1DCACNA1SCYP1A2 | |
| SCHEMBL10770181 | 0.88 | CACNA1C (0.52) | CACNA1CCACNA1FCACNA1DCACNA1SCYP1A2 | |
| SCHEMBL7431518 | 0.87 | CACNA1C (0.53) | CACNA1CCACNA1FCACNA1DCACNA1SCYP1A2 | |
| SCHEMBL10768219 | 0.87 | CACNA1C (0.68) | CACNA1CCACNA1FCACNA1DCACNA1SCYP1A2 | |
| SCHEMBL7430546 | 0.86 | CACNA1C (0.53) | CACNA1CCACNA1FCACNA1DCACNA1SCYP1A2 | |
| SCHEMBL10755859 | 0.85 | TBXA2R (0.58) | CACNA1CCACNA1FCACNA1DCACNA1SCYP1A2 | |
| SCHEMBL7428629 | 0.85 | CACNA1C (0.48) | CACNA1CCACNA1FCACNA1DCACNA1SCYP1A2 | |
| SCHEMBL7430572 | 0.85 | CACNA1C (0.63) | CACNA1CCACNA1FCACNA1DCACNA1SCYP1A2 | |
| SCHEMBL7271185 | 0.84 | CACNA1C (0.47) | CACNA1CCACNA1FCACNA1DCACNA1SCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4686217-A | HYPOTENSIVE AGENTS, CARDIOVASCULAR DISORDERS | FISONS PLC (GB) | 1987-08-11 | — | — | US | disclosed |
| EP-0125803-A2 | Pharmaceutically active dihydropyridines | FISONS plc (GB) | 1984-11-21 | — | — | EP | disclosed |