⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7295398 | 0.94 | — | — | |
| SCHEMBL7315384 | 0.94 | NPY1R (0.49) | — | |
| SCHEMBL9828132 | 0.92 | KDM1A (0.44) | — | |
| SCHEMBL9828417 | 0.91 | KDM1A (0.47) | — | |
| SCHEMBL7286369 | 0.90 | NPY1R (0.47) | — | |
| SCHEMBL7310356 | 0.86 | NPY1R (0.55) | — | |
| SCHEMBL7300955 | 0.86 | NPY1R (0.49) | — | |
| SCHEMBL7430491 | 0.86 | EBP (0.40) | — | |
| SCHEMBL7304585 | 0.86 | NPY1R (0.48) | — | |
| Arpromidine SCHEMBL7279923 | 0.86 | NPY1R (0.61) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0448765-B1 | Use of guanidine derivatives for the manufacture of a medicament with NPY-antagonistic activity | HEUMANN PHARMA GMBH & CO (DE) | 1994-08-17 | — | — | EP | claimed |
| WO-1992022295-A1 | USE OF GUANIDINE DERIVATIVES IN THE PREPARATION OF A DRUG FOR THE TREATMENT OF SEPSIS AND SEPSIS-LIKE CONDITIONS AND SEPTIC SHOCK | NEUGEBAUER EDMUND (DE) | 1992-12-23 | — | — | WO | claimed |
| EP-0448765-A1 | Use of guanidine derivatives for the manufacture of a medicament with NPY-antagonistic activity | HEUMANN PHARMA GMBH & CO (DE) | 1991-10-02 | — | — | EP | claimed |
| WO-1992022295-A1 | USE OF GUANIDINE DERIVATIVES IN THE PREPARATION OF A DRUG FOR THE TREATMENT OF SEPSIS AND SEPSIS-LIKE CONDITIONS AND SEPTIC SHOCK | NEUGEBAUER EDMUND (DE) | 1992-12-23 | — | — | WO | disclosed |