Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.80 |
| ▸ | POLB | P06746 | 1/20 | 0.73 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14565997 | 0.98 | CHRM1 (0.78) | CHRM1POLBCYP1A2CYP2C9KDM4E | |
| SCHEMBL2017763 | 0.95 | CHRM1 (0.82) | CHRM1POLBCYP1A2CYP2C9KDM4E | |
| Procodazole SCHEMBL349966 | 0.89 | CHRM1 (1.00) | CHRM1POLBCYP1A2CYP2C9KDM4E | |
| Procodazole SCHEMBL29404024 | 0.89 | CHRM1 (1.00) | CHRM1POLBCYP1A2CYP2C9KDM4E | |
| Procodazole SCHEMBL838841 | 0.89 | CHRM1 (1.00) | CHRM1POLBCYP1A2CYP2C9KDM4E | |
| SCHEMBL1231977 | 0.85 | GAA (0.76) | CHRM1KDM4EMAPTALDH1A1 | |
| SCHEMBL7006523 | 0.85 | POLB (1.00) | CHRM1POLBNPC1RAB9A | |
| Procodazole SCHEMBL5413283 | 0.85 | CHRM1 (0.91) | CHRM1POLBCYP1A2CYP2C9KDM4E | |
| SCHEMBL721483 | 0.84 | HDAC3 (0.70) | CHRM1POLBKDM4E | |
| SCHEMBL718972 | 0.84 | HDAC3 (0.70) | CHRM1POLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5140011-A | Hypotensive agents | HOFFMANN-LA ROCHE, INC. (US) | 1992-08-18 | — | — | US | disclosed |
| EP-0391179-A2 | Peptide derivatives of amino acids having a renin-inhibiting effect | F. HOFFMANN-LA ROCHE AG (CH) | 1990-10-10 | — | — | EP | disclosed |