SCHEMBL7433477

SCHEMBL7433477

O=C1OC(CCN2CCSCC2)(c2ccccc2)CC(O)=C1SCc1ccccc1

nearest known ligand 0.42

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
LDHA P00338 11/20 0.42
LDHB P07195 5/20 0.34
CDK1 P06493 1/20 0.32
CCNB1 P14635 1/20 0.32
EGFR P00533 1/20 0.32
CHRM2 P08172 2/20 0.31
LTA4H P09960 1/20 0.31
LMNA P02545 1/20 0.31
ADRA2A P08913 1/20 0.31
CYP2D6 P10635 1/20 0.31
TSHR P16473 1/20 0.31
DRD1 P21728 1/20 0.31
SIGMAR1 Q99720 2/20 0.31
S100A4 P26447 1/20 0.30
DRD2 P14416 1/20 0.30
CHRM3 P20309 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7446413 0.94 LDHA (0.41) LDHALDHBCDK1CCNB1EGFR
SCHEMBL7449879 0.93 LDHA (0.40) LDHALDHBLMNATSHRSIGMAR1
SCHEMBL7449735 0.89 LDHA (0.43) LDHALDHBCHRM2SIGMAR1S100A4
SCHEMBL7446700 0.89 LDHA (0.43) LDHALMNACYP2D6SIGMAR1
SCHEMBL7436058 0.88 LDHA (0.42) LDHALDHBCHRM2LTA4HLMNA
SCHEMBL7445853 0.85 LDHA (0.40) LDHALDHB
SCHEMBL7438988 0.84 LDHA (0.39) LDHALMNATSHRSIGMAR1
SCHEMBL7443249 0.83 MAPK1 (0.44) LDHALMNASIGMAR1
SCHEMBL7441018 0.83 LDHA (0.41) LDHALDHBCHRM2SIGMAR1CHRM3
SCHEMBL7440990 0.83 LDHA (0.39) LDHALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0729463-B1 5,6-DIHYDROPYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE DAVIS & CO (US) 2002-05-22 EP claimed
WO-1995014011-A2 5,6-DIHYDROPYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1995-05-26 WO claimed
EP-0729463-B1 5,6-DIHYDROPYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE DAVIS & CO (US) 2002-05-22 EP disclosed
EP-1142887-A1 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents PARKE, DAVIS & COMPANY (US) 2001-10-10 EP disclosed
US-5936128-A BENZENETHIOL COMPOUNDS AS INTERMEDIATES; BACTERICIDES, VIRICIDES; HIV WARNER-LAMBERT COMPANY (US) 1999-08-10 US disclosed
US-5840751-A ADMINISTERING IN THE TREATMENT OF INFECTION OR DISEASE CAUSED BY A RETROVIRUS WARNER-LAMBERT COMPANY (US) 1998-11-24 US disclosed
US-5789440-A 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents WARNER-LAMBERT COMPANY (US) 1998-08-04 US disclosed
EP-0729464-A1 5,6-DIHYDROPYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1996-09-04 EP disclosed
EP-0729463-A1 5,6-DIHYDROPYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE DAVIS & COMPANY (US) 1996-09-04 EP disclosed
WO-1995014012-A1 5,6-DIHYDROPYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1995-05-26 WO disclosed
WO-1995014011-A2 5,6-DIHYDROPYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1995-05-26 WO disclosed