Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY10 | O00398 | 1/20 | 0.40 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.40 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.38 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.38 |
| ▸ | ZDHHC7 | Q9NXF8 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 2/20 | 0.35 |
| ▸ | PNLIP | P16233 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7433486 | 1.00 | P2RY10 (0.40) | P2RY10GPR174GRIK1GRIK2ZDHHC7 | |
| SCHEMBL7430691 | 0.95 | GRIK1 (0.39) | P2RY10GPR174GRIK1GRIK2ZDHHC7 | |
| SCHEMBL7430683 | 0.95 | GRIK1 (0.39) | P2RY10GPR174GRIK1GRIK2ZDHHC7 | |
| SCHEMBL7436145 | 0.87 | GRIK1 (0.41) | P2RY10GPR174GRIK1GRIK2ZDHHC7 | |
| SCHEMBL7436142 | 0.87 | GRIK1 (0.41) | P2RY10GPR174GRIK1GRIK2ZDHHC7 | |
| SCHEMBL16007027 | 0.83 | P2RY10 (0.52) | P2RY10GPR174ZDHHC7MAPTMEN1 | |
| SCHEMBL16007025 | 0.83 | P2RY10 (0.52) | P2RY10GPR174ZDHHC7MAPTMEN1 | |
| SCHEMBL16330498 | 0.83 | ZDHHC7 (0.45) | ZDHHC7LTA4HCA1CA2CYP1A2 | |
| SCHEMBL21364176 | 0.81 | P2RY10 (0.50) | P2RY10GPR174ZDHHC7MEN1FAAH | |
| SCHEMBL28495742 | 0.81 | P2RY10 (0.50) | P2RY10GPR174ZDHHC7MEN1FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1020612-C | METHOD FOR PREPARING ANTIHYPERTENSIVE TRICYCLIC LACTAM DERIVS. | MERRELL PHARMA INC (US) | 1993-05-12 | — | — | CN | disclosed |
| US-4973585-A | INHIBITORS OF ANGIOTENSIN CONVERTING ENZYME | MERRELL DOW PHARMACEUTICALS (US) | 1990-11-27 | — | — | US | disclosed |
| CN-87104166-A | Antihypertensive medicine | — | 1988-01-20 | — | — | CN | disclosed |
| EP-0249223-A2 | Novel antihypertensive agent | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-12-16 | — | — | EP | disclosed |