Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 14/20 | 0.67 |
| ▸ | PDE3A | Q14432 | 14/20 | 0.67 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.67 |
| ▸ | PDE4A | P27815 | 7/20 | 0.67 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.67 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | NPY1R | P25929 | 1/20 | 0.43 |
| ▸ | NPY2R | P49146 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7483850 | 0.84 | PDE3B (0.70) | PDE3BPDE3APDE4BPDE4APDE4C | |
| Indolidan SCHEMBL29605502 | 0.80 | PDE3B (1.00) | PDE3BPDE3APDE4BPDE4APDE4C | |
| Indolidan SCHEMBL124043 | 0.80 | PDE3B (1.00) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL10518523 | 0.75 | PDE3B (0.90) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL7636343 | 0.75 | PDE3B (0.64) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL9371306 | 0.74 | PDE3B (0.60) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL10595977 | 0.73 | PDE3B (0.64) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL10520070 | 0.73 | PDE3B (1.00) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL9372484 | 0.73 | PDE3B (0.62) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL10517412 | 0.73 | PDE3B (1.00) | PDE3BPDE3APDE4BPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4647564-A | PYRIDAZINONE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1987-03-03 | — | — | US | disclosed |
| EP-0161918-A2 | Indoline and 2-indolinone derivatives | ELI LILLY AND COMPANY (US) | 1985-11-21 | — | — | EP | disclosed |