Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.52 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.43 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.42 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.42 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.42 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.42 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1337450 | 0.94 | CYP11B1 (0.54) | TSHRHSD17B10CYP11B1CYP11B2POLB | |
| SCHEMBL1338556 | 0.87 | CYP11B1 (0.60) | CYP11B1CYP11B2POLBMAPTHTT | |
| SCHEMBL22146949 | 0.85 | HPGD (0.46) | TSHRHPGDEPHX2PDE3BPDE3A | |
| SCHEMBL27537788 | 0.83 | TSHR (0.46) | TSHRHSD17B10CYP11B1CYP11B2HDAC1 | |
| SCHEMBL3628694 | 0.83 | CYP11B1 (0.56) | TSHRHSD17B10CYP11B1CYP11B2HPGD | |
| SCHEMBL21169244 | 0.83 | TSHR (0.57) | TSHRHSD17B10MAPTHDAC1FAAH | |
| SCHEMBL20717646 | 0.82 | FFAR1 (0.61) | MAPTHDAC1HDAC2 | |
| Hydrochloric Acid SCHEMBL3628690 | 0.82 | CYP11B1 (0.55) | TSHRHSD17B10CYP11B1CYP11B2HPGD | |
| SCHEMBL29165966 | 0.81 | FFAR1 (0.48) | HDAC1FAAHPDE3BPDE3AP2RY12 | |
| SCHEMBL25169991 | 0.81 | FAAH (0.59) | HSD17B10MAPTFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0725059-B1 | 2,3-DIAMINOPROPIONIC ACID DERIVATIVE | SUMITOMO PHARMA (JP) | 2001-01-17 | — | — | EP | disclosed |
| US-6048854-A | ANTICOAGULANTS; ANTICANCER AGENT; WOUND HEALING AGENTS;BONE DISORDERS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2000-04-11 | — | — | US | disclosed |
| US-5707994-A | USEFUL AS A PLATELET AGGREGATION INHIBITOR, CANCER METASTASIS INHIBITOR, WOUND HEALING AGENT OR A BONE RESORPTION INHIBITOR | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1998-01-13 | — | — | US | disclosed |
| EP-0502536-B1 | Phenyl amidines derivatives useful as platelet aggregation inhibitors | SEARLE & CO (US) | 1996-10-09 | — | — | EP | disclosed |
| EP-0725059-A1 | 2,3-DIAMINOPROPIONIC ACID DERIVATIVE | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1996-08-07 | — | — | EP | disclosed |
| US-5481021-A | Phenyl amidines derivatives useful as platelet aggregation inhibitors | G. D. SEARLE & CO. (US) | 1996-01-02 | — | — | US | disclosed |
| EP-0574545-B1 | PHENYL AMIDINES DERIVATIVES USEFUL AS PLATELET AGGREGATION INHIBITORS | SEARLE & CO (US) | 1994-11-30 | — | — | EP | disclosed |
| EP-0574545-A1 | PHENYL AMIDINES DERIVATIVES USEFUL AS PLATELET AGGREGATION INHIBITORS. | SEARLE & CO (US) | 1993-12-22 | — | — | EP | disclosed |
| WO-1992015607-A2 | PHENYL AMIDINES DERIVATIVES USEFUL AS PLATELET AGGREGATION INHIBITORS | G.D. SEARLE & CO. (US) | 1992-09-17 | — | — | WO | disclosed |
| EP-0502536-A1 | Phenyl amidines derivatives useful as platelet aggregation inhibitors | G.D. Searle & Co. (US) | 1992-09-09 | — | — | EP | disclosed |