Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.60 |
| ▸ | CRHBP | P24387 | 1/20 | 0.58 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | MYOC | Q99972 | 1/20 | 0.47 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.46 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.46 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.46 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.46 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.45 |
| ▸ | TLR4 | O00206 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL177838 | 0.80 | KDM4E (1.00) | KDM4EFFAR1CRHBPCRHR2ALDH1A1 | |
| SCHEMBL31504019 | 0.80 | KDM4E (0.72) | KDM4EFFAR1CRHBPCRHR2ALDH1A1 | |
| SCHEMBL2227754 | 0.79 | PRSS1 (0.63) | ALDH1A1MEN1KMT2AMAPTLMNA | |
| SCHEMBL11601386 | 0.79 | KDM4E (0.76) | KDM4EFFAR1CRHBPCRHR2ALDH1A1 | |
| SCHEMBL177829 | 0.79 | KDM4E (0.76) | KDM4EFFAR1CRHBPCRHR2ALDH1A1 | |
| SCHEMBL7632953 | 0.79 | ALDH1A1 (0.77) | KDM4EFFAR1CRHBPCRHR2ALDH1A1 | |
| SCHEMBL27188054 | 0.79 | ALDH1A1 (0.77) | KDM4EFFAR1CRHBPCRHR2ALDH1A1 | |
| SCHEMBL177676 | 0.78 | FFAR1 (0.71) | KDM4EFFAR1CRHBPCRHR2ALDH1A1 | |
| SCHEMBL668647 | 0.78 | FFAR1 (0.71) | KDM4EFFAR1CRHBPCRHR2ALDH1A1 | |
| SCHEMBL10912746 | 0.77 | FFAR1 (0.62) | KDM4EFFAR1CRHBPCRHR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1107954-A1 | 2-OXO-$i(2H)-QUINOLINE DERIVATIVES | MERCK PATENT GmbH (DE) | 2001-06-20 | — | — | EP | disclosed |
| WO-2000012479-A1 | 2-OXO-2H-QUINOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2000-03-09 | — | — | WO | disclosed |