SCHEMBL7434313

SCHEMBL7434313

COc1cc(C(C)C)c2c(c1)S(=O)(=O)N(COC(=O)c1c(Cl)cccc1Cl)C2=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
ELANE P08246 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7281561 0.91 ELANE (0.84) ELANE
SCHEMBL7436728 0.91 ELANE (0.84) ELANE
SCHEMBL7438847 0.89 ELANE (0.81) ELANE
SCHEMBL7428497 0.89 ELANE (0.81) ELANE
SCHEMBL7437460 0.89 ELANE (0.80) ELANE
SCHEMBL9010431 0.89 ELANE (0.80) ELANE
SCHEMBL7282216 0.89 ELANE (0.80) ELANE
SCHEMBL7288209 0.89 ELANE (0.80) ELANE
SCHEMBL7278118 0.88 ELANE (0.80) ELANE
SCHEMBL7290485 0.88 ELANE (0.79) ELANE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5512589-A TREATING DEGENERATIVE DISEASES STERLING WINTHROP INC. (US) 1996-04-30 US claimed
US-5128339-A Emphysema, rheumatoid arthritis, pancreatitis STERLING WINTHROP INC. (US) 1992-07-07 US claimed
EP-0483928-A1 2-Saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use STERLING WINTHROP INC. (US) 1992-05-06 EP claimed